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Statistical aspects for the design of the study for treatment effect

Abstract

Results from the research question should be reliable and valid, and depend on the scientific design of the study. For results with high precision and no bias, the study should proceed carefully according to a detailed protocol at each stage, including study conducting, data analysis, interpretation, etc., throughout the study period. Statistical design is required to lead the scientific design. Since fallacies at the design stage cannot be completely overcome by statistical adjustment procedures during the study or after the end of the study, full consideration of the whole process is required before the start of the study. In this study, we introduce several key items required in design stage. Statistical problems to be considered are discussed with case examples.

keywords
연구설계, 확률화, 표본크기, 통계분석, study design, randomization, sample size, statistical analysis

Reference

1.

김호일 (2014). 표본추출방법론. 경문사.

2.

성내경 (2012). 실험설계와 분석 제2판. 자유아카데미.

3.

성내경 (2012). 표본조사방법론. 자유아카데미.

4.

이우선, 정형철, 박만식. (2014). 최신 실험설계와 분석. 민영사.

5.

이재원, 박미라, 유한나. (2011). 생명과학연구를위한 통계적 방법론(개정판). 자유아카데미.

6.

Altman, D. (1991). Practical statistics for medical research. Chapman & Hall.

7.

Bailar, J. C., Hoaglin, D. C. (2012). Medical uses of statistics, 3rd Edition, Wiley.

8.

Coolican, H. (2013). Research Methods and Statistics in Psychology, 5th Edition. Routledge.

9.

Cutis, L. M. (1986). Clinical trials. New York:Oxford University Press.

10.

Hulley, S., Cumming, S., Browner, W., Grady, D., Newand, T. (2001). Designing clinical research, 3rd Edition, Wolters Kluwer.

11.

Indrayan, A. (2013). Medical biostatistics. Chapman & Hall.

12.

Robson. C. (1999). Experiment, Design and statistics in psychology, 3rd Edition, Penguin UK.

13.

Wiliamson, J. W., Goldschmidt, P. G., Colton, T. (1986). The quality of medical literature: An analysis of validation assessments. Medical uses of statistics. In:Bailar JC, Mosteller F, ed. Massachusetts Medical Society. Wiley.

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