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Characteristics of Mild Cognitive Impairment Subtypes: An Exploratory Study

Abstract

The purpose of this study is to evaluate the cognitive characteristics of four Mild Cognitive Impairment (MCI) subtypes (amnestic MCI [aMCI]-single domain, aMCI-multiple domain, non-amnestic MCI [naMCI]-single domain, and naMCI-multiple domain), considered the forerunners of dementia, using criteria proposed by Petersen (2004). The Seoul Neuropsychological Screening Battery (SNSB) was administered to 321 participants who complained of impairments in cognitive functions. The patients who were diagnosed for dementia, but whose symptoms were not consistent with MCI classification criteria or who were diagnosed for ‘clinical dementia rating 1’ were excluded. Following this, the data of 109 participants, including the four MCI subtype groups and the normal group, were used for analysis. The results showed that the aMCI-multiple domain group had a lower Rey Complex Figure Test (RCFT) copy score than the aMCI-single domain group, and no significant difference was found in memory area between both groups. The aMCI-single domain group showed a lower level of Seoul Verbal Learning Test (SVLT) immediate recall than the naMCI-single domain group and no significant difference was found in non-memory area between both groups. The aMCI-multiple domain group showed a lower level of RCFT delayed recall than the naMCI-multiple domain group and no significant difference was found in non-memory area between both groups. The implications and limitations of the study and future research directions are also discussed.

keywords
mild cognitive impairment (MCI) subtypes, cognitive characteristics, neuropsychological assessment, 경도인지장애(MCI) 하위유형, 인지적 특성, 신경심리평가

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